I'm a proud fan of the first Disney Infinity but this year's 2.0 version promises to be better in every respect. As well as Disney characters and playsets – Maleficent, Stitch and Merida will appear in there somewhere, and many, many more – there's also Marvel-specific material.
One of the launch playsets will be an Avengers one. Here's the trailer, which gives some idea of the storyline. It all takes place in what they call 'Marvel Manhattan,' which I expect they'll re-use in a Spider-Man playset and maybe others too.
They don't mention it there, but this playset was written by Brian Michael Bendis.
For more detail, there are closer looks at Thor and Hawkeye in these episodes of Toy Box TV, the official Infinity vodcast. The key bit starts just around the 4 minute mark in each video.